発表論文・著書の一覧
平成10年度(1998年)以降の論文・総説・著書を載せてあります。
T.論文
2005年
- T. Akihisa, S. G. Franzblau, M. Ukiya, H. Okuda, F. Zhang, K. Yasukawa, T. Suzuki, Y. Kimura,
Antitubercular activity of triterpenoids from Asteraceae flowers, Biol. Pharm. Bull., 28(1), 158-160 (2005).
- T. Akihisa, H. Tokuda, K. Yasukawa, M. Ukiya, A. Kiyota, N. Sakamoto, T. Suzuki, N. Tanabe, H. Nishino,
Azaphilones, furanoisophthalides, and amino acids from the extracts of Monascus pilosus-fermented rice
(Red-mold rice) and their chemopreventive effects, J. Agric. Food Chem., 53(3), 562-565 (2005).
2004年
- T. Akihisa, H. Tokuda, M. Ukiya, et al.,
3-Epicabraleahydroxylactone and other triterpenoids from camellia oil and their inhibitory effects on Epstein-Barr
virus activation, Chem. Pharm. Bull., 52 (2004) 153-156.
- N. Banno, T. Akihisa, H. Tokuda, K. Yasukawa, et al.,
Triterpe acids from the leaves of Perilla frutescens and their anti-inflammatory and antitumor-promoting effects
, Biosci. Biotechnol. Biochem., 68 (2004) 85-90.
- T. Akihisa, H. Tokuda, M. Ogata, M. Ukiya, M. Iizuka, T. Suzuki, K. Metori, N. Shimizu, H. Nishino,
Cancer chemopreventive effects of polyunsaturated fatty acids, Cancer Lett., 205(1), 9-13, 2004.
- T. Akihisa, Y. Hamasaki, H. Tokuda, M. Ukiya, Y. Kimura, H. Nishino,
Microbial transformation of isosteviol and inhibitory effects on Epstein-Barr virus activation of the
transformation products, J. Nat. Prod., 67(3), 407-410, 2004.
- T. Akihisa, Sh. Mafune, M. Ukiya, Y. Kimura, K. Yasukawa, T. Suzuki, H. Tokuda, N. Tanabe, T. Fukuoka,
(+)- and (-)-syn-2-Isobutyl-4-methylazetidine-2,4-dicarboxylic acid from the extract of monascus
pilosus-fermented rice (red-mold rice), J. Nat. Prod., 67(3), 479-480, 2004.
- T. Akihisa, Y. Mizushina, M. Ukiya, M. Oshikubo, S. Kondo, Y. Kimura, T. Suzuki, T. Tai,
Dehydrotrametenonic acid and dehydroeburiconic acid from Poria cocos and their inhibitory effects
on eukaryotic DNA polymerase α and β, Biosci. Biotechnol. Biochem., 68(2), 448-450, 2004.
- Y. Mizushina, T. Akihisa, M. Ukiya, C. Murakami, I. Kuriyama, X. Xu, H. Yoshida, K. Sakaguchi,
A novel DNA topoisomerase inhibitor: dehydroebriconic acid, one of the lanostane-type triterpene acids from
Poria cocos, Cancer Sci., 95(4), 354-360, 2004.
2003年
- M. Ukiya, T. Akihisa, H. Tokuda, K. Koike, et al.,
Isolation, structural elucidation, and inhibitory effects of terpenoid and lipid constituents from sunflower pollen on
Epstein-Barr virus early antigen induced by tumor promoter, TPA, J. Agric. Food Chem., 51 (2003) 2949-2957.
- M. Ukiya, T. Akihisa, H. Tokuda, K. Koike, et al.,
Sunpollenol and five other rearranged 3,4-seco-tirucallane-type triterpenoids from sunflower pollen and their inhibitory
effects on Epstein-Barr virus activation, J. Nat. Prod., 66 (2003) 1476-1479.
- K. Iwatsuki, T. Akihisa, H. Tokuda, M. Ukiya, et al.,
Sterol ferulates, sterols, and 5-alk(en)ylresorcinols from wheat, rye, and corn bran oil and their inhibitory effects on
Epstein-Barr virus activation, J. Agric. Food Chem., 51 (2003) 6683-6688.
- T. Akihisa, H. Tokuda, M. Ukiya, et al.,
Chalcones, coumarins, and flavanones from the exudate of Angelica keiskei and their chemopreventive effects
, Cancer Lett., 201 (2003) 133-137.
- K. Iwatsuki, T. Akihisa, H. Tokuda, M. Ukiya, et al.,
Lucidenic acids P and Q, methyl lucidenate P, and other triterpenoids from the fungus Ganoderma lucidum and their
inhibitory effects on Epstein-Barr virus activation, J. Nat. Prod., 66 (2003), 1582-1585.
2002年
- M. Ukiya, T. Akihisa, H. Tokuda, H. Suzuki, et al.,
Constituents of Compositae plants III. Anti-tumor promoting effects and cytotoxic activity against human
cell lines of triterpene diols and triols from edible chrysanthemum flowers,
Cancer Lett., 177, 7-12 (2002).
- T. Akihisa, E. M. K. Wijeratne, H. Tokuda, F. Enjo, M. Toriumi, et al.,
Eupha-7,9(11),24-trien-3β-ol ("Antiquol C") and other triterpenes from Euphorbia antiquorum latex and their
inhibitory effect on Epstein-Barr virus activation,
J. Nat. Prod., 65, 158-162 (2002).
- M. Ukiya, T. Akihisa, K. Yasukawa, H. Tokuda, M. Toriumi, et al.,
Anti-inflammatory and anti-tumor-promoting effects of cucurbitane glycosides from the roots of Bryonia dioica,
J. Nat. Prod., 65, 179-183 (2002).
- T. Akihisa, Y. Takamine, K. Yoshizumi, H. Tokuda, et al.,
Microbial transformations of two lupane-type triterpenes and anti-tumor-promoting effects of the transformation
products,
J. Nat. Prod., 65, 278-282 (2002).
- M. Ukiya, T. Akihisa, H. Tokuda, M. Hirano, M. Oshikubo, et al.,
Inhibition of tumor-promoting effects by poricoic acids G and H and other lanostane-type triterpenes and
cytotoxic activity of poricoic acids A and G from Poria cocos,
J. Nat. Prod., 65, 462-465 (2002).
- M. Ukiya, T. Akihisa, H. Tokuda, M. Toriumi, et al.,
Inhibitory Effects of Cucurbitane Glycosides and Other Triterpenoids from the Fruit of Momordica grosvenori on
Epstein-Barr Virus Early Antigen Induced by Tumor Promoter 12-O-Tetradecanoylphorbol-13-Acetate,
J. Agric. Food Chem., 50 (11), 6710-6715 (2002).
2001年
- M. Ukiya, T. Akihisa, K. Yasukawa, et al.,
Constituents of Compositae Plants. 2. Triterpene Diols, Triols, and Their 3-O-Fatty
Acid Esters from Edible Chrysanthemum Flower Extract and Their Anti-inflammatory Effects,
J. Agric. Food Chem., 49(7), 3187-3197 (2001).
- T. Akihisa, J. Ogihara, J. Kato, K. Yasukawa, et al.,
Inhibitory Effects of Triterpenoids and Sterols on Human Immunodeficiency Virus-1 Reverse Transcriptase,
Lipids, 36 (5), 507-512 (2001).
- A. Rajic, T. Akihisa, M. Ukiya, K. Yasukawa, et al.,
Inhibition of trypsin and chymotrypsin by anti-inflammatory triterpenoids from Compositae flowers,
Planta Med., 67 (7), 599-604 (2001).
- T. Akihisa, H. Tokuda, E. Ichiishi, et al.,
Anti-tumor promoting effects of multiflorane-type triterpenoids and cytotoxic activity of karounidiol against
human cancer cell lines,
Cancer Lett., 173 (11), 9-14 (2001).
2000年
- K. Yasukawa, T. Akihisa, Z. Yoshida, M. Takido,
Inhibitory Effect of Euphol, A Triterpene Alcohol from the Roots of Euphorbia kansui, on Tumour
Promotion by 12-O-Tetradecanoylphorbol-13-acetate in Two-stage Carcinogenesis in Mouse Skin
J. Pharm. Pharmacol., 52 (1) 119-124 (2000).
- T. Akihisa, K. Yasukawa, M. Yamaura, M. Ukiya, et al.,
Triterpene Alcohol and Sterol Ferulates from Rice Bran and Their Anti-inflammatory Effects,
J. Agric. Food Chem., 46 (6) 2313-2319 (2000).
- M. Ukiya, T. Akihisa, S. Motohashi, K. Yasukawa, et al.,
6S.8R-Stereochemistry of the C27- and C29-Alkane-6,8-dioles Isolated from Three Compositae Flowers,
Chem. Pharm. Bull., 48 (8) 1187-1189 (2000).
- Z. Chao, B. He, Y. Zhang,, T. Akihisa,
Studies on the Chemical Constituents of Unsaponifiable Lipids from the Seeds of Trichosanthes kirilowii,
Chinese Pharmaceutical Journal, 35 (11) 733-736 (2000).
- S. Motohashi, K. Yasukawa, M. Takido, T. Akihisa, et al.,
Asymmetric Synthesis of Heptacosane-6,8-diols Induced by Chiral Sulfoxides,
Synth. Commun. 30 (24) 4467-4472 (2000).
1999年
- T. Akihisa, K. Arai, Y. Kimura, K. Koike, W. C. M. C. Kokke, T. Shibata, T. Nikaido,
Camelliols A-C, Three Novel Incompletely Cyclized Triterpene Alcohols from Sasanqua Oil
(Camellia sasanqua), J. Nat. Prod., 62, 265 - 268 (1999).
- T. Akihisa, W. C. M. C. Kokke, K. Koike, Y. Kimura, C. Mizukami, A. Sadaie, T. Maruyama, T. Nikaido,
4α-Methyl-5α,14β-ergosta-8,24(241)-dien-3β-ol ("triticusterol"): The First Naturally Occurring
14β(H)-Steroid, J. Chem. Soc. Perkin Trans. 1, 497 - 500 (1999).
- T. Akihisa, R. Hideshima, K. Koike, Y. Kimura, T. Nikaido,
Cycloarta-16,24-dien-3β-ol:Revised Structure of Cimicifugenol, a Cycloartane
Triterpenoid, Chem. Pharm. Bull., 47, 1157-1160 (1999).
- T. Akihisa, Y. Kimura, T. Tai, K. Arai,
Astertarone B, a Hydroxy-Triterpenoid Ketone from the Roots of Aster tataricus L.,
Chem. Pharm. Bull., 47, 1161-1163 (1999).
- K. Yasukawa, T. Akihisa, T. Tamura, M. Takido,
Inhibitory Effect of Cycloartenol Ferulate from Rice Bran on Tumor Promotion in a
Two-Stage Carcinogenesis Mouse Skin Model, Anticancer Res., 19, 3794-3795 (1999).
- T. Akihisa, E. M. Olivares, Y. Kimura, M. Ukiya, F. D. Monache,
(17α,20R)-Dammara-12,24-dien-3β-ol: A Novel Triterpenoid from Clusia
guaviarensis, J. Jpn. Oil Chem. Soc., 48, 1303-1306 (1999).
- T. Akihisa, K. Koike, Y. Kimura, N. Sashida, T. Matsumoto, M. Ukiya, T. Nikaido,
Acyclic and Incompletely Cyclized Triterpene Alcohols in the Seed Oils of Theaceae
and Gramineae, Lipids, 34, 1151-1157 (1999).
- T. Akihisa, Y. Kimura, K. Koike, W. C. M. C. Kokke, T. Ohkawa, T. Nikaido,
(24R)- and (24S)-24-hydroxy-24-vinyllathosterols and other sterols from the aerial
part of Bryonia dioica, Phytochemistry, 52, 1601-1605 (1999).
1998年
- T. Akihisa, Y. Kimura, T. Tamura,
Cycloartane Triterpenes from the Fruit Peel of Musa sapientum, Phytochemistry, 47, 1107 - 1110 (1998).
- T. Akihisa, Y. Kimura, K. Koike, T. Shibata, Z. Yoshida, et al.,
Isohelianol: A 3,4-seco-Triterpene Alcohol from Sasanqua Oil, J. Nat. Prod., 61,
409 - 412 (1998).
- T. Akihisa, K. Yasukawa, Y. Kimura, S. et al.,
Sasanquol, A 3,4-seco-Triterpene Alcohol from Sasanqua Oil, and Its Anti-inflammatory Effect,
Phytochemistry, 48, 301 - 305 (1998).
- K. Yasukawa, T. Akihisa, Y. Kasahara, M. Ukiya, et al.,
Inhibitory Effect of Heliantriol C; a Component of Edible Chrysanthemum, on Tumor Promotion by
12-O-Tetradecanoylphorbol-13-acetate in Two-stage Carcinogenesis in Mouse Skin, Phytomedicine,
5, 215 - 218 (1998).
- K. Yasukawa, T. Akihisa, Y. Kimura, T. Tamura, M. Takido,
Inhibitory Effect of Cycloartenol Ferulate, a Component of Rice Bran, on Tumor Promotion in
Two-stage Carcinogenesis in Mouse Skin, Biol. Pharm. Bull., 21, 1072 - 1076 (1998).
- K. Yasukawa, T. Akihisa, Y. Inoue, et al.,
Inhibitory Effect of the Methanol Extracts from Compositae Plants on 12-O-
Tetradecanoylphorbol-13-acetate-induced Ear Oedema in Mice, Phytother. Res., 12, 484 - 487 (1998).
- T. Akihisa, Y. Kimura, K. Koike, T. Tai, K. Yasukawa, et al.,
Astertarone A: A Triterpenoid Ketone Isolated from the Roots of Aster tataricus L.,
Chem. Pharm. Bull., 46, 1824 - 1826 (1998).
- T. Akihisa, Y. Inoue, K. Yasukawa, Y. Kasahara, et al.,
Widespread Occurrence of syn-Alkane-6,8-diols in the Flowers of the Compositae,
Phytochemistry, 49, 1637 - 1640 (1998).
- T. Akihisa, Y. Kimura, K. Koike, W. C. M. C. Kokke, et al.,
Cycloartane Triterpenoids from the Aerial Part of Bryonia dioica, Phytochemistry,
49, 1757 - 1760 (1998).
U.総説
- 秋久俊博、徳田春邦,
テルペノイドによるがん予防,
オレオサイエンス, 2(6), 19-26 (2002).
- 安川 憲,秋久俊博,
ステロールおよびトリテルペノイドの抗発がんプロモーター活性,
日本油化学会誌, 49 (6) 571-582 (2000).
V.著書
- 秋久俊博、長田洋子、浅田泰男、石塚盛雄、小池一男、神野英毅、西尾俊幸、宮澤三雄 著、
生体分子化学、共立出版(株)(2005).
- 秋久俊博 他共著、
油脂・脂質の基礎と応用−栄養・健康から工業まで−、(社)日本油化学会 (2005).
- 秋久俊博、深津 誠、他共著
油化学辞典−脂質・界面活性剤−,日本油化学会編 (2004).
- T. Akihisa, K. Yasukawa, H. Tokuda
Potentially cancer chemopreventive and anti-inflammatory terpenoids from natural sources,
In “Studies in natural product chemistry, vol. 29, Bioactive natural products” ed. By Atta-ur-Rahman,
Elsevier, Amsterdam, pp.73-126 (2003).
- 秋久、小池、木島、羽野、堀田、増田、宮澤、安川 著、
資源天然物化学、共立出版 (2002).
- T. Akihisa, K. Yasukawa,
Antitumor-promoting and anti-inflammatory activities of triterpenoids and sterols from plants and fungi, Studies
in Natural Products Chemistry, Vol.25 (Atta-ur-Rahman ed.), Elsevier Science B. V., Amsterdam, 43-87 (2001).
- K. Yasukawa, T. Akihisa, Y. Kasahara, K. Kumaki, T. Tamura, S. Yamanouchi, M. Takido, et al.,
Towards Natural Medicine Research in the 21st Century (H. Ageta, N. Aimi, Y. Ebizuka, T. Fujita, G. Honda, eds.),
Elsevier Science B. V., Amsterdam, pp. 207 - 218 (1998).