発表論文・著書の一覧

平成10年度(1998年)以降の論文・総説・著書を載せてあります。

T.論文
    2005年
  1. T. Akihisa, S. G. Franzblau, M. Ukiya, H. Okuda, F. Zhang, K. Yasukawa, T. Suzuki, Y. Kimura, Antitubercular activity of triterpenoids from Asteraceae flowers, Biol. Pharm. Bull., 28(1), 158-160 (2005).
  2. T. Akihisa, H. Tokuda, K. Yasukawa, M. Ukiya, A. Kiyota, N. Sakamoto, T. Suzuki, N. Tanabe, H. Nishino, Azaphilones, furanoisophthalides, and amino acids from the extracts of Monascus pilosus-fermented rice (Red-mold rice) and their chemopreventive effects, J. Agric. Food Chem., 53(3), 562-565 (2005).

    2004年
  3. T. Akihisa, H. Tokuda, M. Ukiya, et al.,
    3-Epicabraleahydroxylactone and other triterpenoids from camellia oil and their inhibitory effects on Epstein-Barr virus activation, Chem. Pharm. Bull., 52 (2004) 153-156.
  4. N. Banno, T. Akihisa, H. Tokuda, K. Yasukawa, et al.,
    Triterpe acids from the leaves of Perilla frutescens and their anti-inflammatory and antitumor-promoting effects , Biosci. Biotechnol. Biochem., 68 (2004) 85-90.
  5. T. Akihisa, H. Tokuda, M. Ogata, M. Ukiya, M. Iizuka, T. Suzuki, K. Metori, N. Shimizu, H. Nishino, Cancer chemopreventive effects of polyunsaturated fatty acids, Cancer Lett., 205(1), 9-13, 2004.
  6. T. Akihisa, Y. Hamasaki, H. Tokuda, M. Ukiya, Y. Kimura, H. Nishino, Microbial transformation of isosteviol and inhibitory effects on Epstein-Barr virus activation of the transformation products, J. Nat. Prod., 67(3), 407-410, 2004.
  7. T. Akihisa, Sh. Mafune, M. Ukiya, Y. Kimura, K. Yasukawa, T. Suzuki, H. Tokuda, N. Tanabe, T. Fukuoka, (+)- and (-)-syn-2-Isobutyl-4-methylazetidine-2,4-dicarboxylic acid from the extract of monascus pilosus-fermented rice (red-mold rice), J. Nat. Prod., 67(3), 479-480, 2004.
  8. T. Akihisa, Y. Mizushina, M. Ukiya, M. Oshikubo, S. Kondo, Y. Kimura, T. Suzuki, T. Tai, Dehydrotrametenonic acid and dehydroeburiconic acid from Poria cocos and their inhibitory effects on eukaryotic DNA polymerase α and β, Biosci. Biotechnol. Biochem., 68(2), 448-450, 2004.
  9. Y. Mizushina, T. Akihisa, M. Ukiya, C. Murakami, I. Kuriyama, X. Xu, H. Yoshida, K. Sakaguchi, A novel DNA topoisomerase inhibitor: dehydroebriconic acid, one of the lanostane-type triterpene acids from Poria cocos, Cancer Sci., 95(4), 354-360, 2004.

    2003年
  10. M. Ukiya, T. Akihisa, H. Tokuda, K. Koike, et al.,
    Isolation, structural elucidation, and inhibitory effects of terpenoid and lipid constituents from sunflower pollen on Epstein-Barr virus early antigen induced by tumor promoter, TPA, J. Agric. Food Chem., 51 (2003) 2949-2957.
  11. M. Ukiya, T. Akihisa, H. Tokuda, K. Koike, et al.,
    Sunpollenol and five other rearranged 3,4-seco-tirucallane-type triterpenoids from sunflower pollen and their inhibitory effects on Epstein-Barr virus activation, J. Nat. Prod., 66 (2003) 1476-1479.
  12. K. Iwatsuki, T. Akihisa, H. Tokuda, M. Ukiya, et al.,
    Sterol ferulates, sterols, and 5-alk(en)ylresorcinols from wheat, rye, and corn bran oil and their inhibitory effects on Epstein-Barr virus activation, J. Agric. Food Chem., 51 (2003) 6683-6688.
  13. T. Akihisa, H. Tokuda, M. Ukiya, et al.,
    Chalcones, coumarins, and flavanones from the exudate of Angelica keiskei and their chemopreventive effects , Cancer Lett., 201 (2003) 133-137.
  14. K. Iwatsuki, T. Akihisa, H. Tokuda, M. Ukiya, et al.,
    Lucidenic acids P and Q, methyl lucidenate P, and other triterpenoids from the fungus Ganoderma lucidum and their inhibitory effects on Epstein-Barr virus activation, J. Nat. Prod., 66 (2003), 1582-1585.

    2002年
  15. M. Ukiya, T. Akihisa, H. Tokuda, H. Suzuki, et al.,
    Constituents of Compositae plants III. Anti-tumor promoting effects and cytotoxic activity against human cell lines of triterpene diols and triols from edible chrysanthemum flowers, Cancer Lett., 177, 7-12 (2002).
  16. T. Akihisa, E. M. K. Wijeratne, H. Tokuda, F. Enjo, M. Toriumi, et al.,
    Eupha-7,9(11),24-trien-3β-ol ("Antiquol C") and other triterpenes from Euphorbia antiquorum latex and their inhibitory effect on Epstein-Barr virus activation, J. Nat. Prod., 65, 158-162 (2002).
  17. M. Ukiya, T. Akihisa, K. Yasukawa, H. Tokuda, M. Toriumi, et al.,
    Anti-inflammatory and anti-tumor-promoting effects of cucurbitane glycosides from the roots of Bryonia dioica, J. Nat. Prod., 65, 179-183 (2002).
  18. T. Akihisa, Y. Takamine, K. Yoshizumi, H. Tokuda, et al.,
    Microbial transformations of two lupane-type triterpenes and anti-tumor-promoting effects of the transformation products, J. Nat. Prod., 65, 278-282 (2002).
  19. M. Ukiya, T. Akihisa, H. Tokuda, M. Hirano, M. Oshikubo, et al.,
    Inhibition of tumor-promoting effects by poricoic acids G and H and other lanostane-type triterpenes and cytotoxic activity of poricoic acids A and G from Poria cocos, J. Nat. Prod., 65, 462-465 (2002).
  20. M. Ukiya, T. Akihisa, H. Tokuda, M. Toriumi, et al.,
    Inhibitory Effects of Cucurbitane Glycosides and Other Triterpenoids from the Fruit of Momordica grosvenori on Epstein-Barr Virus Early Antigen Induced by Tumor Promoter 12-O-Tetradecanoylphorbol-13-Acetate, J. Agric. Food Chem., 50 (11), 6710-6715 (2002).

    2001年
  21. M. Ukiya, T. Akihisa, K. Yasukawa, et al.,
    Constituents of Compositae Plants. 2. Triterpene Diols, Triols, and Their 3-O-Fatty Acid Esters from Edible Chrysanthemum Flower Extract and Their Anti-inflammatory Effects, J. Agric. Food Chem., 49(7), 3187-3197 (2001).
  22. T. Akihisa, J. Ogihara, J. Kato, K. Yasukawa, et al.,
    Inhibitory Effects of Triterpenoids and Sterols on Human Immunodeficiency Virus-1 Reverse Transcriptase, Lipids, 36 (5), 507-512 (2001).
  23. A. Rajic, T. Akihisa, M. Ukiya, K. Yasukawa, et al.,
    Inhibition of trypsin and chymotrypsin by anti-inflammatory triterpenoids from Compositae flowers, Planta Med., 67 (7), 599-604 (2001).
  24. T. Akihisa, H. Tokuda, E. Ichiishi, et al.,
    Anti-tumor promoting effects of multiflorane-type triterpenoids and cytotoxic activity of karounidiol against human cancer cell lines, Cancer Lett., 173 (11), 9-14 (2001).

    2000年
  25. K. Yasukawa, T. Akihisa, Z. Yoshida, M. Takido,
    Inhibitory Effect of Euphol, A Triterpene Alcohol from the Roots of Euphorbia kansui, on Tumour Promotion by 12-O-Tetradecanoylphorbol-13-acetate in Two-stage Carcinogenesis in Mouse Skin J. Pharm. Pharmacol., 52 (1) 119-124 (2000).
  26. T. Akihisa, K. Yasukawa, M. Yamaura, M. Ukiya, et al.,
    Triterpene Alcohol and Sterol Ferulates from Rice Bran and Their Anti-inflammatory Effects, J. Agric. Food Chem., 46 (6) 2313-2319 (2000).
  27. M. Ukiya, T. Akihisa, S. Motohashi, K. Yasukawa, et al.,
    6S.8R-Stereochemistry of the C27- and C29-Alkane-6,8-dioles Isolated from Three Compositae Flowers, Chem. Pharm. Bull., 48 (8) 1187-1189 (2000).
  28. Z. Chao, B. He, Y. Zhang,, T. Akihisa,
    Studies on the Chemical Constituents of Unsaponifiable Lipids from the Seeds of Trichosanthes kirilowii, Chinese Pharmaceutical Journal, 35 (11) 733-736 (2000).
  29. S. Motohashi, K. Yasukawa, M. Takido, T. Akihisa, et al.,
    Asymmetric Synthesis of Heptacosane-6,8-diols Induced by Chiral Sulfoxides, Synth. Commun. 30 (24) 4467-4472 (2000).

    1999年
  30. T. Akihisa, K. Arai, Y. Kimura, K. Koike, W. C. M. C. Kokke, T. Shibata, T. Nikaido,
    Camelliols A-C, Three Novel Incompletely Cyclized Triterpene Alcohols from Sasanqua Oil (Camellia sasanqua), J. Nat. Prod., 62, 265 - 268 (1999).
  31. T. Akihisa, W. C. M. C. Kokke, K. Koike, Y. Kimura, C. Mizukami, A. Sadaie, T. Maruyama, T. Nikaido,
    4α-Methyl-5α,14β-ergosta-8,24(241)-dien-3β-ol ("triticusterol"): The First Naturally Occurring 14β(H)-Steroid, J. Chem. Soc. Perkin Trans. 1, 497 - 500 (1999).
  32. T. Akihisa, R. Hideshima, K. Koike, Y. Kimura, T. Nikaido,
    Cycloarta-16,24-dien-3β-ol:Revised Structure of Cimicifugenol, a Cycloartane Triterpenoid, Chem. Pharm. Bull., 47, 1157-1160 (1999).
  33. T. Akihisa, Y. Kimura, T. Tai, K. Arai,
    Astertarone B, a Hydroxy-Triterpenoid Ketone from the Roots of Aster tataricus L., Chem. Pharm. Bull., 47, 1161-1163 (1999).
  34. K. Yasukawa, T. Akihisa, T. Tamura, M. Takido,
    Inhibitory Effect of Cycloartenol Ferulate from Rice Bran on Tumor Promotion in a Two-Stage Carcinogenesis Mouse Skin Model, Anticancer Res., 19, 3794-3795 (1999).
  35. T. Akihisa, E. M. Olivares, Y. Kimura, M. Ukiya, F. D. Monache,
    (17α,20R)-Dammara-12,24-dien-3β-ol: A Novel Triterpenoid from Clusia guaviarensis, J. Jpn. Oil Chem. Soc., 48, 1303-1306 (1999).
  36. T. Akihisa, K. Koike, Y. Kimura, N. Sashida, T. Matsumoto, M. Ukiya, T. Nikaido,
    Acyclic and Incompletely Cyclized Triterpene Alcohols in the Seed Oils of Theaceae and Gramineae, Lipids, 34, 1151-1157 (1999).
  37. T. Akihisa, Y. Kimura, K. Koike, W. C. M. C. Kokke, T. Ohkawa, T. Nikaido,
    (24R)- and (24S)-24-hydroxy-24-vinyllathosterols and other sterols from the aerial part of Bryonia dioica, Phytochemistry, 52, 1601-1605 (1999).

    1998年
  38. T. Akihisa, Y. Kimura, T. Tamura,
    Cycloartane Triterpenes from the Fruit Peel of Musa sapientum, Phytochemistry, 47, 1107 - 1110 (1998).
  39. T. Akihisa, Y. Kimura, K. Koike, T. Shibata, Z. Yoshida, et al.,
    Isohelianol: A 3,4-seco-Triterpene Alcohol from Sasanqua Oil, J. Nat. Prod., 61, 409 - 412 (1998).
  40. T. Akihisa, K. Yasukawa, Y. Kimura, S. et al.,
    Sasanquol, A 3,4-seco-Triterpene Alcohol from Sasanqua Oil, and Its Anti-inflammatory Effect, Phytochemistry, 48, 301 - 305 (1998).
  41. K. Yasukawa, T. Akihisa, Y. Kasahara, M. Ukiya, et al.,
    Inhibitory Effect of Heliantriol C; a Component of Edible Chrysanthemum, on Tumor Promotion by 12-O-Tetradecanoylphorbol-13-acetate in Two-stage Carcinogenesis in Mouse Skin, Phytomedicine, 5, 215 - 218 (1998).
  42. K. Yasukawa, T. Akihisa, Y. Kimura, T. Tamura, M. Takido,
    Inhibitory Effect of Cycloartenol Ferulate, a Component of Rice Bran, on Tumor Promotion in Two-stage Carcinogenesis in Mouse Skin, Biol. Pharm. Bull., 21, 1072 - 1076 (1998).
  43. K. Yasukawa, T. Akihisa, Y. Inoue, et al.,
    Inhibitory Effect of the Methanol Extracts from Compositae Plants on 12-O- Tetradecanoylphorbol-13-acetate-induced Ear Oedema in Mice, Phytother. Res., 12, 484 - 487 (1998).
  44. T. Akihisa, Y. Kimura, K. Koike, T. Tai, K. Yasukawa, et al.,
    Astertarone A: A Triterpenoid Ketone Isolated from the Roots of Aster tataricus L., Chem. Pharm. Bull., 46, 1824 - 1826 (1998).
  45. T. Akihisa, Y. Inoue, K. Yasukawa, Y. Kasahara, et al.,
    Widespread Occurrence of syn-Alkane-6,8-diols in the Flowers of the Compositae, Phytochemistry, 49, 1637 - 1640 (1998).
  46. T. Akihisa, Y. Kimura, K. Koike, W. C. M. C. Kokke, et al.,
    Cycloartane Triterpenoids from the Aerial Part of Bryonia dioica, Phytochemistry, 49, 1757 - 1760 (1998).
U.総説
  1. 秋久俊博、徳田春邦,
    テルペノイドによるがん予防, オレオサイエンス, 2(6), 19-26 (2002).
  2. 安川 憲,秋久俊博,
    ステロールおよびトリテルペノイドの抗発がんプロモーター活性, 日本油化学会誌, 49 (6) 571-582 (2000).
V.著書
  1. 秋久俊博、長田洋子、浅田泰男、石塚盛雄、小池一男、神野英毅、西尾俊幸、宮澤三雄 著、
    生体分子化学、共立出版(株)(2005).
  2. 秋久俊博 他共著、
    油脂・脂質の基礎と応用−栄養・健康から工業まで−、(社)日本油化学会 (2005).
  3. 秋久俊博、深津 誠、他共著
    油化学辞典−脂質・界面活性剤−,日本油化学会編 (2004).
  4. T. Akihisa, K. Yasukawa, H. Tokuda Potentially cancer chemopreventive and anti-inflammatory terpenoids from natural sources, In “Studies in natural product chemistry, vol. 29, Bioactive natural products” ed. By Atta-ur-Rahman, Elsevier, Amsterdam, pp.73-126 (2003).
  5. 秋久、小池、木島、羽野、堀田、増田、宮澤、安川 著、
    資源天然物化学、共立出版 (2002).
  6. T. Akihisa, K. Yasukawa,
    Antitumor-promoting and anti-inflammatory activities of triterpenoids and sterols from plants and fungi, Studies in Natural Products Chemistry, Vol.25 (Atta-ur-Rahman ed.), Elsevier Science B. V., Amsterdam, 43-87 (2001).
  7. K. Yasukawa, T. Akihisa, Y. Kasahara, K. Kumaki, T. Tamura, S. Yamanouchi, M. Takido, et al., Towards Natural Medicine Research in the 21st Century (H. Ageta, N. Aimi, Y. Ebizuka, T. Fujita, G. Honda, eds.), Elsevier Science B. V., Amsterdam, pp. 207 - 218 (1998).